Carbohydrate mimetics as potential antiinfective treatments for Staphylococcus aureus
نویسندگان
چکیده
منابع مشابه
Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections
Staphylococcus aureus is a commensal bacterium and pathogen. Identifying biomarkers for the transition from colonization to disease caused by this organism would be useful. Several S. aureus small RNAs (sRNAs) regulate virulence. We investigated presence and expression of 8 sRNAs in 83 S. aureus strains from 42 patients with sepsis or septic shock and 41 asymptomatic colonized carriers. Small p...
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The rapid growth of staphylococci in the usual laboratory media consisting of meat infusion or meat extract, peptone, buffer, and metabolizable carbohydrate is accompanied by the consumption of sugar and the production of much acid; only relatively slight changes are noted in the nitrogenous constituents (Kendall, Farmer, Bagg, and Day (1)). Kendall, Friedemann, and Ishikawa (2) obtained a yiel...
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Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed characterization of a corresponding synthetic fDLP (micasin) from a dermatophyte in terms of its structure, activity and therapeutic potential. NMR analysis showed that synthetic micasin adopts a "hallmark" cysteine-stabilized α-h...
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Comparative studies were made of the metabolic activities of a strain of Staphylococcus aureus grown in iron-poor and iron-rich trypticase medium, with and without glucose. Four nutritionally distinctive types of organisms were produced : iron-rich without glucose (Fe + G ) ; ironpoor without glucose (Fe G ) ; iron-rich with glucose (Fe + G + ) ; iron-poor with glucose (FeG + ) . Fe+ G cocci ox...
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Introduction Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. Nuclear medicine has an important role in helping the diagnosis of deep-seated infections by developing more specific radiopharmaceuticals. The aim of this study was to evaluate 99mTc-labeling ceftriaxone as a new radiopharmaceutical for Staphylococcus aureus infection imag...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.859.20